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Orexin peptides and receptors were discovered independently in 1998 by two research groups. Sakurai and co-workers discovered two peptides that produced robust Ca2+ elevation through activation of two receptors which they expressed in CHO cells [1]. The two peptides were named orexin-A and -B, and the receptor subtypes were designated as OX1 and OX2 receptors according to the Greek word for appetite, oreksis (ὄρεξις), since the peptides induced feeding in mice. De Lecea and co-workers discovered about simultaneously a mRNA sequence expressed in hypothalamus that encodes the precursor of the two peptides [6]. They named the peptides hypocretins 1 and 2.

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